Versatile, flexible and biocompatible elastomeric microtubes

公开(公告)号:
SG10202008596SA
公开(公告)日:
2020-10-29
申请号:
SG10202008596S
申请日:
2017-03-02
授权日:
-
受理局:
新加坡
专利类型:
发明申请
简单法律状态:
审中
法律状态/事件:
公开
IPC分类号:
-
战略新兴产业分类:
前沿新材料
国民经济行业分类号:
-
当前申请(专利权)人:
NATIONAL UNIVERSITY OF SINGAPORE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | SHANGHAI JIAO TONG UNIVERSITY
原始申请(专利权)人:
NATIONAL UNIVERSITY OF SINGAPORE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | SHANGHAI JIAO TONG UNIVERSITY
当前申请(专利权)人地址:
21 LOWER KENT RIDGE ROAD SINGAPORE 119077 | 77 MASSACHUSETTS AVENUE CAMBRIDGE, MA 02139 | 800 DONGCHUAN ROAD MINHANG DISTRICT SHANGHAI, 200240
工商统一社会信用代码:
1210000042500615X0
工商登记状态:
正常登记
工商注册地址:
上海市华山路1954号
工商成立日期:
1861-04-10|1905-01-01|1896-01-01
工商企业类型:
其他
发明人:
XI, WANG | LIM, CHWEE, TECK | KONG, FANG | GONG, XIAOBO
代理机构:
-
代理人:
AMICA LAW LLC
摘要:
The present invention relates to a flexible polymer-based microtube having an inner diameter of about 4 μm to about 1000 μm and a variable outer diameter, wherein the cross- sectional shape of the microtube can be, for instance, circular, rectangular, square, triangular, elliptical, star or irregular. The present invention also relates to a method of making the flexible microtube and devices incorporating the flexible microtube. No suitable figure.
技术问题语段:
-
技术功效语段:
-
权利要求:
What is claimed is: 1. A flexible microtube comprising a polymer, the microtube having an inner diameter of about 4µm to about 1000 p.m, and a variable outer diameter. 2. The microtube of claim 1, wherein the polymer is a silicone elastomer, an ultraviolet sensitive polymer, a conductive polymer, polyurethane, a thermoplastic polymer, a thermoset polymer, a polyimide, or a conductive rubber. 3. The microtube of claim 2, wherein the silicone elastomer is polydimethylsiloxane, phenyl-vinyl silicone, methyl-siloxane, platinum cured silicone rubber or fluoro- siloxane. 4. The microtube of claim 2, wherein the ultraviolet sensitive polymer is MYpolymer, styrene-acrylate-containing polymer, polyacrylate polyalkoxy silane, a positive photoresist or a negative photoresist. 5. The microtube of claim 1, wherein the microtube inner diameter is between about 10 p.m and about 800 p.m. 6. The microtube of claim 1, wherein the length of the microtube is about 10 m or less. 7. The microtube of claim 1, wherein the microtube is gas permeable. 8. The microtube of claim 1, wherein the microtube is transparent. 9. The microtube of claim 1, wherein the microtube is biocompatible. 10. A method of making a flexible microtube comprising a polymer, the method comprising: immersing a wire into a pool comprising heat curable polymer; heating the wire for a first period of time, thereby initiating curing of the heat curable polymer at the surface of the wire; pulling the wire out of the pool; heating the wire for a second period of time, thereby curing additional heat curable polymer and producing a polymer coated wire; immersing the polymer coated wire in a liquid bath with sonication, thereby loosening the polymer-wire contact; removing the wire from the polymer coated wire, thereby producing a polymeric microtube; and heating the polymeric microtube, thereby producing the flexible microtube of claim 1. 11. The method of claim 10, wherein the heating for a first period of time is performed via electric current along the wire, the heating for a second period of time is performed via a hot air heating element, the liquid bath is an acetone bath, and the heating of the polymeric microtube is performed via baking. 12. A method of making a flexible microtube comprising a polymer, the method comprising: immersing a wire into a pool comprising a pre-cured ultraviolet-curable polymer; pulling the wire out of the pool and into an argon chamber; curing a layer of ultraviolet-curable polymer coated around the wire under an ultraviolet mercury lamp, thereby producing a polymer coated wire; immersing the polymer coated wire in a liquid bath with sonication, thereby loosening the polymer-wire contact; removing the wire from the polymer coated wire, thereby producing a polymeric microtube; and heating the polymeric microtube, thereby producing the flexible microtube of claim 1. 13. A device comprising the microtube of claim 1. 14. The device of claim 13, wherein the device is a biomedical device. 15. The device of claim 14, wherein the biomedical device is an artificial skin, organ-on- chip, blood vessel mimicking device, capillary network mimicking device, opto- microfluidic device, a 3D bioreactor, drug delivery device, cell stretcher, tissue engineering scaffold, micro-pump or micro-valve. 16. The microtube of one of claims 1-9, wherein the microtube has a circular, rectangular, square, triangular, elliptical, star or irregular cross-sectional shape.
技术领域:
-
背景技术:
-
发明内容:
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具体实施方式:
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