权利要求：
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Claims
1. An applicator system for applying a pharmaceutical preparation for topical
administration having a consistency of at least 100 centipoise and less than or
equal to 2000 centipoise at 25 °C to a body surface, comprising a container body
containing the medicament preparation and an applicator detachably attached to
the container body, wherein the applicator means comprises: The application
surface is provided with an application surface capable of receiving the medical
preparation of a single use amount and capable of applying the pharmaceutical
preparation to a body surface, and the application surface is provided. An
applicator system comprising a rigid, non-porous, inelastic material and having a
single concave shape, wherein said application surface is formed from only a
peripheral wall portion leading to a side of said applicator and a bottom portion
surrounded by said peripheral wall portion, said bottom portion forming a single
planar portion.
2. The applicator system of claim 1, wherein said pharmaceutical formulation is a
formulation selected from the group consisting of a gel, a lotion, a cream, a
solution having a consistency of greater than or equal to 100 centipoise and less
than or equal to 1100 centipoise at 25 °C.
3. The applicator system of claim 2, wherein the pharmaceutical formulation is a
formulation having a consistency of greater than or equal to 100 centipoise and
less than or equal to 900 centipoise at 25 °C.
4. An applicator system according to any of claims 1 to 3, wherein said
pharmaceutical formulation is a formulation containing at least 40 w / w% of 1 or
more C 1 - C 4 alcohols.
5. An applicator system according to any of claims 1 to 4, wherein the amount of
use is from 0.1 mL to 1.0 mL.
6. An applicator system according to any of claims 1 to 5, wherein said planar
portion occupies 5% or more of the area of said application surface.
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7. An applicator system according to claim 6, wherein said planar portion
occupies 60% or more of an area of said application surface.
8. An applicator system according to any of claims 1 to 7, wherein a height
difference between a highest portion of the application surface and a lowest
portion of the application surface is in a range of 0.1 to 4.0.
9. The applicator system of claim 8, wherein a height difference between a
highest portion of the application surface and a lowest portion of the application
surface is in a range of 0.1 to 1.5.
10. The applicator system according to any one of claims 1 to 9, wherein the
application surface has a substantially circular planar shape having a diameter of
or more and 45 or less, or a substantially oval planar shape having a major
diameter or a minor diameter of 20 or more and 45 or less.
11. An applicator system according to any of claims 1 to 10, wherein the container
body comprises a bottle portion containing the medicament formulation and a
pump mounted on the mouth of the bottle portion.
12. The applicator system of claim 11, wherein the application surface is
configured to receive a single dose of the pharmaceutical formulation discharged
from the pump.
13. An applicator system according to any of claims 1 to 12, wherein the
pharmaceutical formulation is a formulation containing sofupyronium bromide
used as a hyperhidrosis therapeutic.
14. An applicator system according to any of claims 1 to 13, wherein the
applicator is an applicator applied to an underarm.
15. An applicator for applying a pharmaceutical formulation to a body surface, the
applicator comprising an application surface capable of receiving a single use
amount of the pharmaceutical formulation and capable of applying the
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pharmaceutical formulation to a body surface, wherein the application surface is
adapted to be applied to the body surface. An applicator comprising : a rigid, non-
porous, inelastic material, and a single concave, wherein said application surface
is formed solely from an outer peripheral wall portion leading to a side of said
applicator and a bottom portion surrounded by said outer peripheral wall portion,
said base portion forming a single planar portion.
16. The applicator of claim 15, wherein the amount of use is from 0.1 mL to 1.
mL.
17. An applicator according to claim 15 or 16, wherein said planar portion
occupies 5% or more of the area of said application surface.
18. The applicator of claim 17, wherein said planar portion occupies 60% or more
of an area of said application surface.
19. An applicator according to any one of claims 15 to 18, wherein a height
difference between a highest portion of the application surface and a lowest
portion of the application surface is in a range of 0.1 to 4.0.
20. The applicator according to claim 19, wherein a height difference between a
highest portion of the application surface and a lowest portion of the application
surface is in a range of 0.1 to 1.5.
21. The applicator according to any one of claims 15 to 20, wherein the
application surface has a substantially circular planar shape having a diameter of
or more and 45 or less, or a substantially oval planar shape having a major
diameter or a minor diameter of 20 or more and 45 or less.
22. An applicator according to any of claims 15 to 21, wherein said applicator is
an applicator applied to an underarm.
23. An applicator for applying a pharmaceutical formulation to a body surface of a
patient in need of said pharmaceutical formulation, said applicator comprising a
generally cylindrical, substantially elliptical cylindrical or substantially
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polygonal tubular side wall having a cavity defining a boundary of said cavity,
said cavity having an open lower end and a closed upper end. A container or
dispenser for holding a pharmaceutical formulation, wherein the outer surface of
the closed upper end of the applicator comprises a central continuous planar
portion and a raised peripheral portion defining a boundary of the planar portion,
wherein the planar portion is configured to be releasably engaged with a
container or dispenser. An applicator, comprising : a) a reservoir region ; and b) a
reservoir region, wherein said planar portion and said peripheral region together
form a reservoir region, and wherein said reservoir region is adapted to receive a
pharmaceutical formulation dispensed into said planar portion and to retain said
pharmaceutical formulation in said reservoir region.
24. The applicator of claim 23, wherein the applicator has a circular or oval planar
portion inside the raised peripheral portion.
25. An applicator according to claim 23 or 24, wherein said side wall comprises a
holding portion for gripping said applicator or for easily manipulating said
applicator.
26. An applicator according to any one of claims 23 to 25, further comprising an
overcap covering at least said planar portion of said applicator.
27. An applicator according to any one of claims 23 to 26, wherein said planar
portion of said outer surface of said applicator is provided. An applicator which
functions to apply ejected one or more doses of a pharmaceutical formulation to
a body surface of a patient, wherein the raised periphery functions to retain the
dispensed pharmaceutical formulation in the reservoir region defined by the
planar portion and the peripheral portion while the pharmaceutical formulation is
being administered.
28. An applicator according to any one of claims 23 to 27, wherein said body
surface is an underarm skin surface of said patient.
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29. An applicator system for applying a pharmaceutical formulation to a body
surface of a patient, the container containing a plurality of doses of the
pharmaceutical formulation and optionally having a dispenser for dispensing the
pharmaceutical formulation. A system comprising : a container or an applicator
releasably engaged with the dispenser; and a generally cylindrical, substantially
oval cylindrical or substantially polygonal tubular side wall defining a cavity and
defining a boundary of the cavity, wherein the cavity is a substantially cylindrical
or substantially polygonal cylindrical or substantially polygonal tube. An open
lower end and a closed upper end, wherein the outer surface of the closed upper
end of the applicator includes a central continuous planar portion and a raised
peripheral portion defining a boundary of the planar portion, wherein the planar
portion has an open end. An applicator system, which is rigid and non-porous,
and wherein said peripheral portion together with said planar portion forms a
reservoir region, and wherein said applicator portion further functions as an
applicator for receiving and retaining said dispensed pharmaceutical formulation
in said reservoir region and applying said same to said patient's body surface.
30. The applicator system of claim 29, further comprising an overcap engaging
said applicator and covering at least said planar portion of said applicator.
31. An applicator system according to claim 29 or 30, wherein said container has
a dispenser for dispensing said pharmaceutical formulation and further
comprises a piston inside said container. An applicator system which slides to
reduce a storage volume of contents in a container each time a single use
amount is dispensed, and ultimately ejects substantially all of the medicament
formulation from the container.
32. An applicator system as claimed in claim 31, wherein the container further
comprises a lower end open to the environment, whereby the pressure within the
container is equalized after the pharmaceutical formulation has been dispensed
from the container.
33. An applicator system according to claim 29 or claim 30, wherein the container
is a container. An applicator system comprising a collapsible inner liner disposed
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within a container, wherein the inner liner reduces a storage volume of contents
in the container each time a single dose is dispensed and compresses the
contents to ultimately expel substantially all of the pharmaceutical formulation
from the container.
34. The applicator system of claim 32, wherein the container includes a lower cap
that mates with the container.
35. An applicator system according to any of claims 29 to 34, wherein the
container includes a pump dispenser.
36. The applicator system of claim 35, wherein the pump dispenser is a metering
pump dispenser.